What is Pregabalin?
Pregabalin is an anti-epileptic drug, also called as anticonvulsant. Pregabalin commonly used to relive pain caused by nerve damage due to diabetes or shingles. Pregabalin is available as prescription medicine under the brand name LYRICA in UK,US (manufactured by Pfzier Limited ) AVERTZ cap in India (manufactured by DR. REDDY’S). Other common brands are GABAFIT, GABANEXT, GABAMAX, GABAVOLT. You can buy Pregabalin in the US, UK, Canada, and India with an online prescription. Pregabalin is available in various doses such as 25mg; 50 mg, 100mg. Commonly reported side effects of pregabalin include: infection, ataxia, blurred vision, constipation, diplopia (double vision), dizziness, drowsiness, fatigue, headache, peripheral oedema, tremor, weight gain, visual field loss, accidental injury, and xerostomia, suicidal tendency. Pregabalin may make you dizzy or drowsy so it is advised not to perform activities such as driving a car or operate machinery while on pregabalin. One should not drink alcohol while taking pregabalin as it can add the drowsiness caused by this medication. Certain prescription and over the counter drugs such as vitamins, ACE inhibitors, diabetic drugs may have undesirable reaction with pregabalin.
How does Pregabalin work?
Pregabalin acts on your central nervous system. Pregabalin is a derivative of gamma-amino butyric acid (GABA) ( responsible for exchange of information and impulse within the brain) with anti-convulsant, anti-epileptic, anxiolytic, and analgesic activities. Pregabalin works by calming the damaged or overactive nerves in your body that may cause pain or seizures. Although the exact mechanism of action is unknown, pregabalin selectively binds to subunits of nerve cells located in the central nervous system (CNS) so that release of various neurotransmitters (Neurotransmitters are chemical messengers that send message from a nerve cell across the synapse to a target cell) including glutamate, norepinephrine, serotonin, dopamine, and substance P, is inhibited and nerve cell excitability is diminished.
Benefits of taking Pregabalin
Pregabalin capsules, oral solution (liquid), and extended-release (long-acting) tablets are used to treat pain from damaged nerves (neuropathic pain) that happens with diabetes, healing of shingles, fibromyalgia (pain all over your body) pain that follows spinal cord injury, certain types of seizures in adults and children 1 month of age and older. Treatment with pregabalin is associated with improvement in all forms of insomnia and improvement in sleep and for generalised anxiety disorder.
How should you take Pregabalin?
Pregabalin is taken through the mouth with a glass of water. It has to be taken as recommended by the physician 2-3 times depending on the medical condition. The dosage of the drug depends on the type of condition the patient dealing with, an initial dosage of 50mg given for diabetic neuropathy where the dosage may increase to 150-300 mg if the patient is having post therapeutic neuralgia. In terms of safety and tolerability, Pregabalin has been shown to demonstrate good safety in children and adults at the optimal doses. For children weighing <30 kg, a dose increases of 40% (mg/kg dosing) is required to achieve comparable exposure with adults or children weighing ≥30 kg.